Antibacterial Agents Laboratory
[ State Certificate ]

Head of laboratory 

 

 

 

 

 

 

 

 

 

 

 

 

Kazmirchuk V.V., Ph.D., M.D.

 

Staff:

Shulga N. M., leading researcher, Ph.D.

Andreieva I. D., leading researcher, Ph.D., M.D.

Evsyukova V. Yu., senior researcher, Ph.D., M.D.

Volyanskaya N.O., senior researcher

Radchenko O.O., senior researcher

Povolokina I.V., senior researcher

Klysa T.L., senior researcher

Yudin I. P., researcher

Scherbak O. M., researcher

Chumachenko O.O., junior research assistant

Scrypnic V.D., laboratory assistant

Miroshnic N.I., laboratory assistant

Ivanova I.M., laboratory assistant

 

                                                      

 

LIST OF PH. D. STUDENTS OF THE LABORATORY

 - full-time Ph.D. student:

Malanchuk S. G. (terms of study 01.11.2009 31.10.2012), scientific supervisor Volyanskiy A. Yu.;

Moiseenko Т. M. (terms of study 01.11.2011 31.07.2014), scientific supervisor Volyanskiy Yu. L.;

 

- part-time Ph. D. student:

Maslyanchuk О. А. – (terms of study 01.11.2010 – 31.10.2014), scientific supervisor Kuchma I. Yu.;

Parusova Ya. Yu. – (terms of study 01.11.2009 – 31.10.2013), scientific supervisor Volyanskiy Yu. L.;

Solonіna N. L. – (terms of study 01.11.2010 – 31.10.2014), scientific supervisor Kuchma I. Yu.;

Chernyayeva T. A. – (terms of study 01.11.2010 – 31.10.2014), scientific supervisor Kuchma I. Yu.;

Kuzmenko Yu. P. – (terms of study 01.11.2010 – 31.10.2014), scientific supervisor Volyanskiy Yu. L.;

Tanasov S. V. – (terms of study 01.11.2011 – 31.10.2015), scientific supervisor Volyanskiy Yu. L.;

Hushylyk B. I. – (terms of study 01.11.2011 – 31.10.2015), scientific supervisor Kuchma I. Yu.;

Melnik A. L.– (terms of study 01.11.2011 – 31.10.2015), scientific supervisor Kazmirchuk V.V.;

 

 

 

RESEARCH PROJECTS OF THE LABORATORY:

1.                 Research АМS 67/2005 «The influence of excipients on the enhancement of the biological activity of antibiotics in dosage forms».

2.                 Research АМS 66/2005 «Development of antimicrobial agents based on biologically active substances of Humulus lupulus L. for infectious and inflammatory diseases treatment ».

3.                 Research АМS 81/2008 «Determination of chemical compounds with antimicrobial activity among synthetic coumarin derivatives and their heteroanalogues for future use in the development of new drugs».

4.                 Research АМS 82/2008 «Development of antimicrobial agents based on hops products for  respiratory diseases treatment».

 

 

CURRENT RESEARCH PERFORMED IN THE LABORATORY:

1. АМS 97/2011 «Theoretical and experimental justification for the development of nanocomposite coatings based on biopolymers and antimicrobial products for medical implants»;

 2. АМS 99/2011 «Antimicrobial activity new derivative condensed nitrocontaining condensed compounds and prospects for building on the basis of preventive and therapeutic tools».

 

 

LIST OF MAJOR SCIENTIFIC PUBLICATIONS:

1.   Synthesis and antimicrobial activity of 3 - [1,2,4-oksadizol 5-yl] coumarins [Теxt] / V. V. Kazmirchuk, A. S. Detistov, I. O. Zhuravel, S. M. Kovalenko // Journal of organic and pharmacological chemistry. – 2007. – V.5, is. 4(20). – P. 41 – 43.

2.   Yudin I. P. Modern approaches to viability assessment of bacteria with accent on nonculturability phenomenon [Electronic source] / I. P. Yudin // Annals of Mechnicov`s Institute. – 2007. – № 3. – P. 8–16. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2007/07yip.nfn.pdf

3.    The development of antimicrobial agents composition with enhanced specific activity [Electronic source] / V. V. Kazmirchuk, I. F. Bilocon, V. Yu. Evsyukova et al.  // Annals of  Mechnicov`s Institute. – 2007. № 4. – P. 39–42. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2007/j42007.htm.

4.   Synthesis and antimicrobial activity of 7-methyl -6-okso-2Н,6Н-tieno[2´,3´:4,5] pyrimido [2,1-b][1,3,4] thiadiazine -8-carboxylic acid derivatives [Теxt] / V.  V. Kazmirchuk, S. M. Kovalenko, S. V. Vlasov et al. // Bulletin of Pharmacy. – 2008. – № 1 (53). – P. 3–7.

5.   Antimicrobial activity of synthetic derivates of condensed heterocyclic compounds with pyridine fragment [Electronic source] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk et al. // Annals of Mechnikov Institute. – 2009. – № 1. – P. 14–18. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2009/j12009.htm.

6.   Antimicrobial activity of Humulus lupulus l. [Теxt] / V. V. Kazmirchuk, M. I. Lyashenko, A. V. Spiridonov et al. // Botanical gardens in the 21st century: the conservation of biodiversity, development strategy and innovative solutions:: Mater. Intern. Scientific-Practical. Conf., Belgorod, 18 - 21 May 2009 - Belgorod: CPI "POLITERRA. – P. 438 – 441.

7.   Prospects for the development of drugs based on condensed heterocyclic compounds for application in obstetrics and gynecology [Теxt] / V. Yu. Evsyukova, I. D. Andreieva, O. M. Scherbak, T. O. Volkov // Challenges, achievements and prospects of biologically health sciences and health: Proceedings of the Crimean State Medical University named after S. S. Georgiyevskiy. Simferopol. : Publishing. center KSMU, 2009. – V. 145. – Part III. – P. 9–11.

8.   Pat. UA 92273 U. МПК (2006): А61К 36/185, А61Р 31/04 The use of carbon dioxide hop extract as an active substance in pharmaceutical formulations with the antimicrobial action / Kazmirchuk V. V. et al.; applicant and the patent owner Kazmirchuk V. V.; SE “Mechnikov Institute for Microbiology and immunology of NAS of Ukraine”- № a200907812; appl. 24/07/2009, publ. 11.10.2010, Bull. Number 19/2010.

9.   Pat. UA 92274 U. МПК (2006): А61К 36/185, А61Р 31/04 The use of alcoholic extract of hops as an active substance in pharmaceutical formulations with the antimicrobial action / Kazmirchuk V. V. [et al.]; applicant and the patent owner Kazmirchuk V. V.; SE “Mechnikov Institute for Microbiology and immunology of NAS of Ukraine”. - № а200907813; appl.  24.07.2009; publ.  11.10.2010, Bull. Number 19/2010.

10.       Volyanskiy Yu. L., Evsyukova V. Yu., V. V. Kazmirchuk, Kuchma I. Yu., Zhuravel I. O., Maslyanchuk O. A., Maryuschenko A. M., Shatylo Y. V., Borisov O . V., Volkov T. O., Rudenko L.M., Andreieva I. D., Makarenko V. D., Shcherbak O. M., Dankovych N. O. 5-hydroxymethyl-2- imino-8-methyl -2Н- pyran[2,3-с]pyridine-3-N-(3- ftorofenil) carboxamide activity against fungi Candida spp. Application for invention № a201001173 from 05.02.2010r.

11.       Evsyukova V.Yu., Volyanskiy A.Yu., Kazmirchuk V. V., Shulga N. M., Zhuravel I. O., Mironenko L. G., Shatylo Yu. V., Borisov O. V., Makarenko V. . D., Peretyatko O. G., Volkov T. O., Grigorchuk O.A., Zamyatina N. M. {2-N-[4-(6-metilbenzotіazolіl-2)fenil]imino-3-N-(2-etilfenіl)carboxamido-8-methyl -2Н-pyran [3,2-с]pyridine-5-il}-меthylacetat antifungal activity against Candida spp. Application for invention № a201001177 from 05.02.2010r.

12.       Тhe antibacterial properties of condensed heterocyclic compounds (review) [Electronic source] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk, O. A. Маslyanchuk // Annals of Mechnikov Institute. – 2010. – № 1. – С. 510. Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2010/j12010.htm.

13.       Microbiological basis of application of 7-azacumarines in infectious diseases [Теxt] / V. Yu. Evsyukova, I. D. Andreieva, V. D. Makarenko, І. О. Zhuravel // East European Journal of Public Health. – 2010. –  № 1(9). – P.143-144.

14.       7- azacumarines - promising compounds with antimicrobial properties [Теxt] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk, O. M. Scherbak // Clin. Microbiol. Antimicrob. Chemother. - 2010. –V.12. – № 2. – Ap. 1. – P. 26.

15.       Evsyukova V. Yu. Antifungal activity of the derivatives of 7 - azacumarines [Text] / V. Yu. Evsyukova, I. D. Andreieva, V. V.Kazmirchuk // Bulletin of the problems of biology and medicine.– 2010. – № 2. – P. 156–159.

16.       Andreieva I. D. Experimental basis of application of 7-azacumarines for urinary tract infections treatment in women  [Text] / I. D. Andreieva // Challenges, achievements and prospects of biologically health sciences and health: Proceedings of the Crimean State Medical University named after S. S. Georgiyevskiy.. – Simferopol. : Publishing. center KSMU, 2010. – V. 149. – P. 4.С. 9–11.

17.       Evsyukova V. Yu. Prospects of 7-azacumarines application in overcoming antibiotics resistance in nosocomial mycotic infections [Text] / V. Yu. Evsyukova // Kharkiv surgical school. – 2010. - № 4(42). – P. 95–98.

18.       Andreieva I. D. The features of 2Н-pyran[2,3-с]pyridines derivatives in treatment of complications of staphylococcal etiologyext] / I. D. Andreieva / / Kharkiv surgical school. – 2010. - № 4(42). – P. 99–102.

19.       Еvsyukova V. Yu. Antimicrobial activity of 2H-piran[2,3-с]piridines derivatives in regards to activity against Enterobacteriaceae spp. [Теxt] / V. Yu. Еvsyukova // Zaporozhye medical journal. – 2010. – № 4. – V. 12. – P. 78–80.

20.       Kazmirchuk V. V. The perspectives of Humulus Lupulus L. products application in treatment of upper respiratory tract infections (review) [Теxt] / V. V. Kazmirchuk, I. D. Andreieva, V. D. Makarenko // Infectious diseases.– 2010. – № 2. – P. 79–84.

21.       Andreieva I. D. The study of antimicrobial activity of of 7-azakumarynes derivatives [Теxt] / I. D. Andreieva // Bulletin of research.– 2010. – № 2. – P. 118–119.

22.       Еvsyukova V. Yu. Effect of 2H-piran[2,3-c]pyridine derivatives on adhesive properties of Candida spp. fungi [Теxt] / V. Yu. Еvsyukova // Bulletin of research.–  – 2010. - № 2. – P. 98 – 100.

23.       Synthesis of 2H, 6H-pyrimido[2,1-b][1,3,4]thiadiazine-6-ones with the coumarin fragment and their antimicrobial activity [Теxt] / S. M. Kovalenko, S. V. Vlasov, А. І. Fedorov et al. // Journal of organic and pharmacological chemistry. – 2010. – V.8. – Is. 3(31). – P. 52–57.

24.       Study of the toxic effects of 2H-piran[2,3-c]pyridines derivatives [Теxt] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk, V. I. Yuchimenko // World of medicine and biology. - №  4. – 2010. – P. 111–113.

25.       Еvsyukova V. Yu. Study of local irritating and sensitizing effects of 2H-pirano[2,3-c]pyridine derivatives [Теxt] / V. Yu. Evsyukova, I. D. Andreieva, V. V.Kazmirchuk // Current issues of the problems of modern medicine: Journal of Ukrainian Medical Stomatological Academy.- 2010. - № 4(32). – V. 10. - P. 68–71.

26.       Evsyukova, V. Yu.  Prospects of 2H-piran [2,3-c] pyridines in overcoming the antibiotic resistance in infectious complications in obstetrics and gynecology [Теxt] / V. Yu. Evsyukova, T. O. Volkov, V. V. Kazmirchuk, O. O. Chumachenko // Taurian Medical Biology Journal. - 2010. – V. 13, 4 (52). – P. 51–53.

27.       Evsyukova, V. Yu. The study of general toxicity of 2Н-pirano[2,3-c]pyridine derivatives [Electronic source] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk et al. // Annals of Mechnikov Institute. – 2011. – № 1. – С. 26–29. Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2011_1/j12011.htm.

28.       Scherbak, O. M. Potential of the 4H-pyrido[4 ', 3': 5,6]pyrano[2,3-d] pyrimidine derivatives in overcoming spread of antibiotic resistance [Теxt] / / O. M. Scherbak, I. D. Andreieva, V. V. Kazmirchuk, V. Yu. Evsyukova // Clin. Microbiol. Antimicrob. Chemother. - 2011. –V.13. – № 2. – Ap. 1. – P. 39.

29.       Antifungal activity of the of the new derivative of condensed nitrocontaining heterocycles with the pyrimidin fragment against Candida spp./ [Теxt] / O. Scherbak, I. Andreieva, V. Kazmirchuk et al. // Problems of medical mycology. – 2011. – V. 13. - № 2. – P. 123 – 124.

30.       Scherbak O. M. Results of primary microbiological screening of the new condensed nitrocontaining heterocycles with the pyrimidin fragment derivatives [Теxt] / O. M. Scherbak, I. D. Andreieva, V. V. Kazmirchuk // Bulletin of the problems of biology and medicine. – 2011. – 2. – V. 3 ( 86 ). - P. 171 – 173.

31.       Scherbak, O. M. Prospects for the study of antimicrobial activity of new derivatives of 4H-pyrido[4 ', 3': 5,6] pyran[2,3-d] pyrimidine [Теxt] / О. М. Scherbak  // Current issues of pharmaceutical and medical science and practice– 2011. –V. ХХIV, № 2. – P. 116 – 118.

32.       Scherbak, O. M. Prospects of  application of condensed nitrocontaining heterocycles with the pyrimidin fragment derivatives in otomicosis [Теxt] / O. M. Scherbak, I. D. Andreieva, D. M. Chernyshenko et al.  // Bulletin of research. – 2011. – V. 63. - № 2. – P. 111 – 112.

33.       Kazmirchuk, V. V. Development of a medicinal agent for topical application from hops for treatment of sinusitis [Теxt] / V. V. Kazmirchuk, I. V. Povolokina, O. O. Radchenko et al. // Bulletin of research. – 2011. - № 2 ( 63 ). – P. 109 – 110.

34.       Scherbak O. M. Activity of the derivatives of 4N-pirido [4 ´, 3 ':5,6] pirano [2,3-d]pyrimidine against Candida spp. fungi [Теxt] / O. M. Scherbak, I. D. Andreieva, V. V. Kazmirchuk  //  World of medicine and biology – 2011. - № 3. - P. 41- 44.

35.       Sherbak, O. M. Study of the acute toxicity of 4N-pirido [4 ´, 3 ':5,6] pirano [2,3-d]pyrimidine derivatives [Теxt] / O. M. Scherbak, I. D. Andreieva, V. V. Kazmirchuk et al. // Current issues of pharmaceutical and medical science and practice.– 2011. – V. XXIV, № 3. – P. 100 – 103.

36.       Shulga, N. M. The antimicrobial properties of nanocomposite materials based on calcium phosphate and chitosan [Теxt] / N. M. Shulga, L. B. Suchodub, A. A. Yanovskaya et al. // Nanotechnology in pharmacy and medicine materials Intern. Science. - Practical. conf., Kharkov, 13 -14 October 2011. - Kh, 2011. - P. 248.

37.       Scherbak O. M. Activity of condensed nitrocontaining heterocycles with the pyrimidin fragment derivates against gram-positive bacteria [Теxt] / O. M. Scherbak, I. D. Andreieva, V. V. Kazmirchuk // Kharkiv surgical school. - 2011. – № 5. – P. 48–51.

38.       Radchenko, O. O. Preparations based on phenic hydrophilic substances of propolis and their application in therapy of infectious diseases [Electronic source] / O. O. Radchenko, N. M. Shulga, B. I. Gushylyk et al. // Annals of Mechnikov Institute. – 2011. - № 4. – P. 312-313. Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2011_4/index.htm

39.       Suchodub, L. B. Biocompatible calcium-phosphate coatings for metallic implants [Electronic source] / L. B. Suchodub, A. Yu. Volyanskiy, L. F. Suchodub et al. // Annals of Mechnikov Institute. – 2011. - №4. – P. 252 - 258. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2011_4/index.htm

40.       Pat. 94962 Ua, МПК A61F 2/02 A61K 6/02 A61C 5/08 B05D 1/04. A method for obtaining the crystalline hydroxylapatite coating on the implants and endoprosthesis of titanium and its alloys / Suchodub L. B., Suchodub L. B. applicant and the patent owner Institute of Applied Physics of the Academy of Sciences of Ukraine.. – № а 2009 03282; appl. 06.04.09; publ.25.06.11, Bull. Number № 12.

41.       Application № а201107115 Ua МПК А61К31/33 C07D495/12. 2-(6- hydroxymethyl-9-methyl-2aryl -5Н-pyrido [4`,3`:5,6]pyrano[2,3-d] pirymydyn-4- ilsulfanil)acetamide with antifungal activity [Теxt] / Scherbak O. M., Kuchma I. Yu., Kazmirchuk V. V., Rusak P. S., Zhuravel I. O., Krestetska S. L., Andreieva I. D., Mironenko L. G., Volkov T . O., Lachman S. M., Chernyshenko D. M., Shulga N. M., Pichevska N. I., Golubka O. V., Makarenko V. D. (Ukraine); applicant and the patent owner Kazmirchuk V. V.; SEMechnikov Institute for Microbiology and immunology of NAS of Ukraine”; aappl. 06.06.11.

 

 

 

Hyperlinks on some articles:

1.     Kazmirchuk, V. V. The development of antimicrobial agents composition with enhanced specific activity [Electronic source] / V. V. Kazmirchuk, I. F. Bilocon, V. Yu. Evsyukova et al. // Annals of Mechnicov`s Institute. – 2007. № 4. – P. 39–42. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2007/j42007.htm.

2.     Yudin I. P. Modern approaches to viability assessment of bacteria with accent on nonculturability phenomenon [Electronic resource] / I. P. Yudin // Annals of Mechnicov`s Institute. – 2007. – № 3. – P. 8–16. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2007/07yip.nfn.pdf

3.     Evsyukova, V. Yu. Antimicrobial activity of synthetic derivates of condensed heterocyclic compounds with pyridine fragment [Electronic source] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk et al. // Annals of Mechnikov Institute. – 2009. – № 1. – P. 14–18. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2009/j12009.htm

4.     Evsyukova, V. Yu. Тhe antibacterial properties of condensed heterocyclic compounds (review) [Electronic source] / V. Yu. Evsyukova, I. D. Andreieva, V. V. Kazmirchuk, O. A. Маslyanchuk // Annals of Mechnikov Institute. – 2010. – № 1. – С. 510. Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2010/j12010.htm.

5.     Еvsyukova, V. Yu. Antimicrobial activity of 2H-piran[2,3-с]piridines derivatives in regards to antimicrobial activity against Enterobacteriaceae spp. [Теxt] / V. Yu. Еvsyukova // Zaporozhye medical journal. – 2010. – № 4. – V. 12. – P. 78–80. - Mode of access: http://www.nbuv.gov.ua/portal/chem_biol/zmzh/2010_4/evsuk.pdf

6.     Kazmirchuk, V. V. The perspectives of Humulus Lupulus L. products application in the upper respiratory tract infections treatment (review) [Теxt] / V. V. Kazmirchuk, I. D. Andreieva, V. D. Makarenko // Infectious diseases.– 2010. – № 2. – P. 79–84. - Mode of access http://www.nbuv.gov.ua/portal/chem_biol/infKhvor/2010_2/18.pdf

7.     Kovalenko, S. M. Synthesis of 2H, 6H-pyrimido [2,1-b] [1,3,4] thiadiazine-6-ones with the coumarin fragment and their antimicrobial activity [Теxt] / S. M. Kovalenko, S. V. Vlasov, A. I. Fedorov et al. // Journal of organic and pharmacological chemistry. – 2010. – V.8. – Is. 3(31). – P. 52–57. - Mode of access http://www.nbuv.gov.ua/portal/chem_biol/jofkh/2010_3/52-57.pdf

8.     Еvsyukova, V. Yu. Prospects of 2H-piran [2,3-c] pyridines application in overcoming antibiotic resistance in treatment of infectious complications in obstetrics and gynecology [Теxt] / V. Yu. Evsyukova, T. O. Volkov, V. V. Kazmirchuk, O. O. Chumachenko // Taurian Medical Biology Journal. - 2010. – V. 13, 4 (52). – P. 51–53. - Mode of access: http://www.nbuv.gov.ua/portal/Chem_Biol/Tmbv/2010_4/Evsukova.pdf

9.     Evsyukova, V. Yu. The study of general toxicity of 2Н-pirano[2,3-c]pyridine derivatives [Electronic source] / V. Yu. Evsyukova, I. D.Andreieva, V. V. Kazmirchuk et al. // Annals of Mechnikov Institute. – 2011. – № 1. – С. 26–29. Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2011_1/j12011.htm.

10.              Scherbak, O. M. Antifungal activity of the of the new condensed nitrocontaining heterocycles with the pyrimidin fragment derivatives against Candida spp. [Теxt] / O. Scherbak, I. Andreieva, V. Kazmirchuk et al. // Problems of medical mycology. – 2011. – V. 13. - № 2. – P. 123 – 124. - Mode of access: http://www.rusmedserv.com/mycology/html/mapo_2_2011.pdf

11.              Scherbak, O. M. Prospects of the study of antimicrobial activity of new derivatives of 4H-pyrido [4 ', 3': 5,6] pyran [2,3-d] pyrimidine [Теxt] / О. М. Scherbak  // Current issues of pharmaceutical and medical science and practice– 2011. –V. ХХIV, № 2. – P. 116 – 118. - Mode of access: http://www.zsmu.edu.ua/upload/files/jurnals/aktualni_2011_2.pdf

12.              Scherbak, O. M. Study of the acute toxicity of 4N-pirido [4 ´, 3 ':5,6] pirano [2,3-d]pyrimidine derivatives [Теxt] / O. M. Scherbak, I. D. Andreieva, V. V. Kazmirchuk et al. // Current issues of pharmaceutical and medical science and practice.– 2011. – V. XXIV, № 3. – P. 100 – 103. - Mode of access: http://www.nbuv.gov.ua/portal/Chem_Biol/apfnp/2011_3/zcerbak.pdf

13.              Radchenko, O. O. Preparations based on phenic hydrophilic substances of propolis and their application in therapy of infectious diseases [Electronic source] / O. O. Radchenko, N. M. Shulga, B. I. Gushylyk et al. // Annals of Mechnikov Institute. – 2011. - № 4. – P. 312-313. Mode of access:  http://www.nbuv.gov.ua/e-journals/AMI/2011_4/index.htm

14.              Suchodub, L. B. Biocompatible calcium-phosphate coatings for metalic implants [Electronic source] / L. B. Suchodub, A. Yu. Volyanskiy, L. F. Suchodub et al. // Annals of Mechnikov Institute. – 2011. - №4. – P. 252 - 258. – Mode of access: http://www.nbuv.gov.ua/e-journals/AMI/2011_4/index.htm