Staff

Martynov

Artur Martynov, Pharm.D, PhD, ScD, Professor, head of laboratory

Olena Grishyna, MD, PhD, leader researcher (head of
clinical division)

Lisnyak 

Yury Lisnyak, Mat.D, PhD, leader researcher (head of molecular design division) 

Romanova

Romanova Helen, BD, PhD, leader researcher, (head of immunology division)

Bomko

Bomko Tatyana, BD, PhD, leader researcher  (head of preclinical research division)

Nosalska

Nosalskaya Tatyana, Vet.D.,
PhD, leader researcher

Pogorela

Pogorelaya Marina, BD.,
PhD.,
senior researcher

Shcherbak Olga, MD., PhD., senior researcher

Batrak Helen, Pharm.D., PhD, senior researcher

Brusnik Svetlana, MD, PhD, senior researcher

Sidorenko Tatyana., senior researcher

Igumnova Nataly, senior researcher

Menkus Helen, researcher

Yukhimenko Vera, researcher





LABORATORY AND CLINICAL DEPARTMENT OF MOLECULAR  IMMUNOPHARMACOLOGY

Our Partners:

 

 [Farber's Center for Academic Success LLC & Noigel LLC]
 (New-York, USA)

 

 [School of Medicine of V. N. Karazin Kharkiv National University]
 (Kharkov, Ukraine)


 [North-East Scientific Center of NAS and MES of Ukraine ]
 (Kharkov, Ukraine)

 

 [Kavetsky Institute of Experimental Pathology, Oncology
 and Radiobiology, NASU]

 (Kiev, Ukraine)

 

 [National University of Pharmacy,dpt. of Chemistry of Natural Compounds]
 (Kharkov, Ukraine)

 

 [Kharkiv City Multidisciplinary Hospital №18] 

Priority areas:

 Medicine areas: rheumatoid arthritis; metabolic syndrome; immune system misbalance in somatic pathology;  after vaccination immunity; autoimmune pathology; new drugs and drugs combination in development; new diagnostic methods; clinical study the new drugs and substances (State Agreement for clinical base)

 Pharmacology & Pharmacy areas: drug-design for new antimicrobial, antiviral; anticancer substances; computer modelling of biomolecular systems, structural aspects of biological activity, design for dynamic drugs (self-assembled therapeutical systems); in vitro and in vivo preclinical study the new substances (State Certificate 2019-2022)

 Organic & Electro - chemistry:  bioelectrochemical Ag-Cu catalysis; new Ag-Cu - containing antiseptics for veterinary and agriculture; synthesis and study of quasi-living self-assembled and self-organized system


 Current State Grants from NAMSU:

1. "Studying the conditions and basic patterns of non-covalently inactivating the vaccine's and toxin's antigens producers  with new derivatives of flavins, phenothiazines and quinones"

2. "Study of the electromagnetic radiation resonance effects on the biological activity of urease  and  it's complexes with inhibitors"

3. "Creation of new prevention drugs for preventing reactivation of latent tuberculosis"


 Current ISO-certificates:

ISO-certificate

Publications:

 1. Grishyna, О. I. Apixaban in patients with atrial fibrillation [Text] / О. I. Grishyna, AVERROES Steering Committee and Investigators, S. J. Connolly, J. Eikelboom et al // The New England Journal of Medicine. – 2011. Vol. 364, N 9, P. 806817.

 2.  Grishyna, О. I. Tiotropium versus salmeterol for the prevention of exacerbations of COPD [Text] / О. I. Grishyna A., POET-COPD Investigators, C. Vogelmeier, B. Hederer et al // The New England Journal of Medicine. – 2011. Vol. 364, N 12, P. 10931103.

 3.  Grishyna, О. I. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation [Text] / О. I. Grishyna, ROCKET AF Investigators, M. R. Patel, K. W. Mahaffey et al // The New England Journal of Medicine. – 2011. Vol. 365, N 10, P. 883891.

 4.  Grishyna, О. I. Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial [Text] /  О. I. Grishyna, AVERROES Steering Committee and Investigators, H. C. Diener, J. Eikelboom et al // Lancet Neurol. – 2012. Vol. 11, N 3, P. 225231.

 5. Grishyna, О. I. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF [Text] / О. I. Grishyna, ROCKET AF Steering Committee Investigators, G. J. Hankey, M. R. Patel et al // Lancet Neurol. – 2012. Vol. 11, N 4, P. 315322.

 6.  Grishyna, О. I. Diet and kidney disease in high-risk individuals with type 2 diabetes mellitus [Text] / О. I. Grishyna, ONTARGET Investigators, D. Dunkler, M. Dehghan et al // JAMA Intern Med. – 2013. Vol. 173, N 18, P. 16821692

 7.Grishyna, О. I. Variations in Cause and Management of Atrial Fibrillation in a Prospective Registry of 15,400 Emergency Department Patients in 46 Countries: The RE-LY AF Registry [Text] / О. I. Grishyna, RE-LY Atrial Fibrillation Registry Investigators, J. Oldgren, J. S. Healey et al // Circulation. – 2014. – Vol. 129, N 15. – P. 1568-1576

 8. Grishyna, О. I. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) [Text] / О. I. Grishyna, ROCKET AF Investigators, J. L. Halperin, G. J. Hankey et al // Circulation. – 2014. – Vol. 130, N 2. – P. 138-146

9. Martynov A, Farber B, Farber S. Quasi-life self-organizing systems: based on ensembles of succinylated derivatives of interferon-gamma. Curr Med Chem. 2011;18(22):3431-6.

10. Yuriy V. Lisnyak, Arthur V. Martynov , Vyacheslav N. Baumer, Oleg V. Shishkin and Anna V. Gubskaya. Crystal and molecular structure of β-cyclodextrin inclusion complex with succinic acid // Journal of Inclusion Phenomena and Macrocyclic Chemistry.- 2007.- Volume 58, Numbers 3-4, P. 367-375, DOI 10.1007/s10847-006-9284-x

11. Schemchuk L.A., Chernych V.P., Martynov A.V. Synthesis of trans-aconitic acid imides //RJOC.- 1997.-Vol.33, N 3.-P.1257-1259

12. Martynov A.V., Shmatko Yu.V., Smelyanskaya M.V., Peremot S.D., Vinnik Yu.M. Detection of herpes virus type 1 antigen in lymphocytes and tumor tissue of patients with cancer of uterus // Exp. Oncology. - 2002.- Vol. 24, N 2. – P.120-122

13. Kuchma I.Yu., Volyansky A.Yu., Moskalenko V.F., Tkachuk T.B., Dobroskok A.I., Martynov A.V., Smelyanskaya M.V., Peremot S.D. Using of cis-aconitic acid phenylimides in liposomal form for herpes treatment // J. Micr.Epid.Immunobiol.-2000.- N 5.- P.58-61

14. Martynov AV, Tymchenko OM, Pokhyl SI. Chemically modified specific immunoglobulins for legionellosis laboratory diagnostics Mikrobiol Z. 2005 May-Jun;67(3):61-70.

15. Мartynov А.V., Smelyanskaya M.V. Antiproliferative properties of chemically modified a-2b-recombinant interferon // J. of Interf. & Cytokine res.- 2005.-Vol. 25, N 7.- P. 414-417

16. Martynov A.V. New approach to synthesis of trans-aconitic acid imides // RJOC.-2005.-41(5).- P. 731-734

17. Martynov AV, Tymchenko OM, Pokhyl SI. Effect of succinylation of Klebsiella 45 bacteriophage proteins on specific lytic activity. Mikrobiol Z. 2005 Sep-Oct;67(5):80-8.

18. Martynov AV, Bomko TV,  Nosalskaya TN,   Farber BS, Farber SB. Oral long-acting pharmaceutical form of insulin on the basis of self-organizing kvasi-living system of combinatorial peptides// Annals of Mechnikov Institute, N 2, 2012.-P.64-70


19. Martynov AV,Farber  BS, Farber  SB. The use of antiviral drugs for treatment of cancer patients// Allergy. -2011. -66, Suppl.94.-P.661-662 (Abstr. Conf.)

20.
Martynov AV,Farber  BS, Farber  SB. A new anti-viral drug with a quick, direct effect// 2011 FIP Congress in Hyderabad (India).- Sept.,5.-P.1. (Abstr. Conf.)

21. Martynov AV,Farber  BS, Farber  SB A method useable in clinics for significantly increasing the effectiveness of treating patients with malignant tumors // European journal of Internal medicine.-2011.-Vol.22, Suppl.1.-P. 29-31 //10th Congress of the European Federation of Internal Medicine 5 October - 8 October 2011, Athens Hilton Hotel, Greece (Abstr. Conf.)
 
22.
Martynov AV,Farber  BS, Farber  SB. A new anticancer drug overcomes cancer resistance// FOCIS.-2011.- Abs.Suppl. Washington, June 23-26.- P.122-123  (Abstr. Conf.)
 
23.
US Patent 8846064B2. Cosmetic and pharmaceutical compositions having modified proteins in the form of a supramolecular assembly// Martynov AV,Farber  BS, Farber  SB./ Publ. 30.09.2014. Prior. 02.08.2012

24. Lisnyak Yu.V., Martynov A.V. Molecular modeling of interactions of antimicrobial compounds with cell membrane components: nystatin-ergosterol membrane pore // Annals of Mechnikov’s Institute. – 2012. - № 3. – P. 51-56.

25. Lisnyak Yu.V. Models of amphotericin membrane channel based on concerted  =C-HO intermolecular interactions // Annals of Mechnikov’s Institute. – 2012. - № 3. – P. 33-37.

26. Gubskaya A. V., Khan I. J., Valenzuela L. M., Lisnyak Yu. V., Kohn J. Investigating the release of a hydrophobic peptide from matrices of biodegradable polymers: an integrated method approach // Polymer. - 2013. – Vol. 54, N 15. – P. 3806-3820.


27. Lisnyak Yu.V. Molecular modeling study of the contributions of side amino acid residues of polymyxin B3 to its binding with E.coli outer membrane lipopolysaccharide // Annals of Mechnikov’s Institute. – 2014. – N4. – P. 44-54.


28. Lisnyak Yu. V. Molecular targets of nephrotoxic action of polymyxins // Annals of Mechnikov’s Institute. – 2015. – N3. – P. 8-24.  


29. Lisnyak Yu. V.  Molecular dynamics study of interactions of polymyxin B3 and its Ala-mutants with lipopolysaccharide // Annals of Mechnikov’s Institute. – 2015. – N4.


30. Bomko TV, Martynov AV, Nosalska TN, & Kabluchko TV. (2016). «KING OF PROBIOTICS» BACILLUS COAGULANS IN MODERN COMBINED PROBIOTIC PREPARATIONS LAKTOVIT FORTE (FULL REVIEW). Annals of Mechnikov Institute, (1), 17–37. http://doi.org/10.5281/zenodo.167502


31.
Martynov AV, Farber BS, Osolodchenko TP, Farber SB, & Kabluchko TV. (2016). DEPENDENCE BETWEEN ACYLATION DEGREE AND SPECIFIC LYSIS ACTITIVY OF THE PSEUDOMONAS AERUGINOSA М6 BACTERIOPHAGE. Annals of Mechnikov Institute, (2), 16–20. http://doi.org/10.5281/zenodo.167488

32. Nosalskaya TN, Martynov AV, Bomko TV, & Kabluchko TV. (2016). BACILLUS COAGULANS EFFICIENCY IN TREATING ANTIBIOTIC-ASSOCIATED DIARRHEA IN IMMUNODEFICIENCY MICE. Annals of Mechnikov Institute, (2), 28–33. http://doi.org/10.5281/zenodo.167490

33. Martynov AV, Bomko TV, Nosalskaya TN, Lisnyak Yu.V, Romanova EA, Kabluchko TV, … Farber SB. (2016). TUBERCULOSIS AS AN INFECTIOUS PATHOLOGY OF IMMUNE SYSTEM. Annals of Mechnikov Institute, (3), 8–14. http://doi.org/10.5281/zenodo.167423

34. Lisnyak Yu. V, & Martynov AV. (2016). STRUCTURAL ORGANIZATION OF BACTERIAL UREASES. Annals of Mechnikov Institute, (3), 22–30. http://doi.org/10.5281/zenodo.167426

35.Pohorila MS, Martynov AV, Romanova OA, Sidorenko TA, Igumnova NI, Yukhimenko VI, & Shcherbak OM. (2016). NEW FORMYL-PEPTIDES, AS STIMULATOR OF NON-SPECIFIC ORGANISM RESISTANCE AGAINST MYCOBACTERIA. Annals of Mechnikov Institute, (3), 49–52. http://doi.org/10.5281/zenodo.167430

36. Sukhodub, L.B, Khrystian, G.E, Sukhodub, L.F, Shulga, N.M, Meshkov, A.M, Kazmirchuk, V.V.,, & Martynov, A.V. (2016). COMPOSITE MATERIALS BASED ON ZINC SULFIDE AND ZINC OXIDE: STRUCTURAL AND BIOCIDAL PROPERTIES. Annals of Mechnikov Institute, (4), 34–39. http://doi.org/10.5281/zenodo.192298

37. Martynov, A.V, Batrak, E.A, & Kabluchko, T.V. (2016). HPLC FOR CONTROL STABILITY OF QUERCETIN INJECTABLE DOSAGE. Annals of Mechnikov Institute, (4), 53–57. http://doi.org/10.5281/zenodo.192301

38. Kabluchko, TV, Bomko, TV, Nosalskaya, TN, Martynov, AV, & Osolodchenko, TP. (2017). SURVIVAL OF MICROORGANISMS FROM MODERN PROBIOTICS IN MODEL CONDITIONS OF THE INTESTINE. Annals of Mechnikov Institute, (1), 28–33. http://doi.org/10.5281/zenodo.401068

39. Melnik, AL, Kazmіrchuk, VV, Nosalska, TM, Bomko, TV, Dovga, IM, Povolokina, IV, … Martynov, AV. (2017). PHARMACOLOGICAL RESEARCH OF THE DENTAL GEL WITH CARBON DIOXIDE HUMULUS LUPULUS EXTRACT. Annals of Mechnikov Institute, (1), 62–66. http://doi.org/10.5281/zenodo.401073

40. Martynov, AV, Bomko, TV, Nosalskaya, TN, Kabluchko, TV, Igumnova, N.I, Romanova, EA, … Farber, SB. (2017). THE PHARMACOLOGICAL EFFICACY OF THE EXTEMPORANEOUS GEL DIAVENOL. Annals of Mechnikov Institute, (1), 67–70. http://doi.org/10.5281/zenodo.401074


41. Martynov, A.V., Bomko, T.V., Nosalskaya, T.N., & Kabluchko-Baruah, T.V. (2017). STRUCTURES AND BIOLOGICAL ACTIVITY OF CUPROPHYLLINS. Annals of Mechnikov Institute, (2), 7–14. http://doi.org/10.5281/zenodo.803832


42.
Martynov, A.V., Bomko, T.V., Nosalskaya, T.N., & Kabluchko-Baruah, T.V. (2017). STRUCTURES AND BIOLOGICAL ACTIVITY OF CUPROPHYLLINS. Annals of Mechnikov Institute, (2), 7–14. http://doi.org/10.5281/zenodo.803832

43. Lisnyak, Yu. V., & Martynov, A. V. (2017). Homology modeling and molecular dynamics study of Mycobacterium tuberculosis urease. Annals of Mechnikov Institute, (3), 23–36. http://doi.org/10.5281/zenodo.1000132

44. Lisnyak, Yu. V.,, & Martynov, A. V. (2017). Ligand-binding sites on the Mycobacterium tuberculosis urease. Annals of Mechnikov Institute, (3), 37–46. http://doi.org/10.5281/zenodo.1000136

45. Myronenko, L. G., Peretyatko, O. G., Iagniuk, J. A., & Martynov, A. V. (2017). Influence of gentamicin on enterococci biofilm formation. Annals of Mechnikov Institute, (3), 51–55. http://doi.org/10.5281/zenodo.1000142

46. Martynov, A. V., Romanova, E. A., Pohorila, M. S., Shcherbak, O. M., Sidorenko, T. A., Igumnova, N. I., & Yukhimenko, V. I. (2017). New formyl peptide has the stimulating properties in point of immune system cells. Annals of Mechnikov Institute, (3), 62–66. http://doi.org/10.5281/zenodo.1000146

47. Grishyna O. I., Babinets O. M., Menkus O. V., & Kalchenko G. R. (2017). PROPHYLAXIS OF INFLUENZA IN THE ELDERY. IS THERE ANY ALTERNATIVE?. Annals of Mechnikov Institute, (4), 6–12. http://doi.org/10.5281/zenodo.1133761

48.Pohorila М.S., Romanova E.А., Martynov A.V., Іgumnova N.І., Sidorenko Т.А., Yukhimenko V.І., & Shcherbak O.M. (2017). VITAMIN D3: RESEARCH BREAKTHROUGHS AND THERAPEUTIC USE. Annals of Mechnikov Institute, (4), 13–20. http://doi.org/10.5281/zenodo.1133763

49. Manuilov A. M., & Martynov A.V. (2017). THE ANALYSIS OF THE THREAT OF REUSING PET BOTTLES FOR THE STORAGE OF DRINKING WATER. Annals of Mechnikov Institute, (4), 26–32. http://doi.org/10.5281/zenodo.1133769

50. Bomko T. V., Martynov A. V., & Nosalskaya T. N. (2017). THE STUDY OF SOME PROMISING PHARMACEUTICAL COMPOSITIONS WITH UREASE INHIBITORY ACTIVITY FOR THE TUBERCULOSIS REACTIVATION PREVENTION. Annals of Mechnikov Institute, (4), 43–45. http://doi.org/10.5281/zenodo.1133775

51.
Lisnyak, Yu. V., & Martynov, A. V. (2018). MOLECULAR DYNAMICS STUDY OF QUERCETIN AND SOME OF ITS SUCCINYL DERIVATIVES IN AQUEOUS SOLUTION. Annals of Mechnikov Institute, (N 1), 6–15. http://doi.org/10.5281/zenodo.1214609

52. Manuilov, A.M., & Martynov, A.V. (2018). ANTISEPTIC SPRAY BASED ON STABILIZED SILVER PARTICLES: AN ANALYSIS OF ANTISEPTIC PROPERTIES AND COMPREHENSIVE COMPARISON. Annals of Mechnikov Institute, (1), 21–27. http://doi.org/10.5281/zenodo.1214619

53. Gorodnitskaya, N.I., Gabysheva, L.N., Derkach, S.A., & Martynov, A.V. (2018). IMMUNOPROPHYLAXIS OF PSEUDOMONOSIS: ACHIEVEMENTS AND PERSPECTIVES. Annals of Mechnikov Institute, (2), 5–15. http://doi.org/10.5281/zenodo.1303954

54.Bomko, T.V., Martynov, A.V., Nosalskaya, T.N., Manuilov, A.M., & Manuilov, M. B. (2018). INFLUENCE OF SILVER PREPARATIONS ON LIVING ORGANISMS. Annals of Mechnikov Institute, (3), 7–14. http://doi.org/10.5281/zenodo.1456501

55. Shcherbak, V.V., Shcherbak, O.M., Martynov, A.V., & Pohorila, M.S. (2018). DEFINITION OF MATHEMATICAL MODELS OF SHOTS DISTANCE DETERMINATION USING BIOLOGICAL IMITATORS OF HUMAN TISSUES. Annals of Mechnikov Institute, (3), 57–61. http://doi.org/10.5281/zenodo.1456573

56. Farber, B.S., Martynov, A.V., & Kleyn, I.R. (2018). CREATION OF NEW MEDICAL DRUGS BASED ON TRIZ AND COMPUTER MATHEMATICAL MODELING. Annals of Mechnikov Institute, (4), 15–34. http://doi.org/10.5281/zenodo.2547580

57.Lisnyak, Yu. V., & Martynov, A. V. (2018). DOCKING STUDY OF MOLECULAR MECHANISM BEHIND THE QUERCETIN INHIBITION OF MYCOBACTERIUM TUBERCULOSIS UREASE. Annals of Mechnikov Institute, (4), 54–60. http://doi.org/10.5281/zenodo.2547472

58. Farber, B., Martynov, A., Osolodchenko, T., & Kleyn, I. (2019). APPLICATION OF SYNERGETIC SET OF TRIZ PRICIPLES FOR DEVELOPING cAMP - ACCUMULATION ACTIVATORS AND THEIR INFLUENCE ON MULTI-DRUG RESISTANCE MICROORGANISMS. Annals of Mechnikov Institute, (1), 47–54. http://doi.org/10.5281/zenodo.2639505

59. Martynov, A., Didenko, G., Farber, B., Farber, S., & Cruts, O. (2018). The anticancer activity of antisense micro RNA (fRNA) in combination with the lectin from Bacillus subtilis B‐7025. Journal of Pharmacy and Pharmacology, 70(6), 732-739.

60. Bomko, T. V., Nosalskaya, T. N., Kabluchko, T. V., Lisnyak, Y. V., & Martynov, A. V. (2017). Immunotropic aspect of the Bacillus coagulans probiotic action. Journal of Pharmacy and Pharmacology, 69(8), 1033-1040.

 

 
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