Head of the Laboratory

 

Andrew Volyanskiy

Doctor of Medical Sciences

  Scientific direction

Currently, the laboratory is accumulating fundamentally new information on the role of infectious agents, particularly herpesvirus, in general human pathology, the logical conclusion of which is expected to result in the development of a new concept of the role and importance of persistent intracellular infections both in general human pathology and in adaptive capacity of the body under physiological conditions of existence.

The considerable expansion of infectious diseases requires the formation of a new paradigm of herpesvirus infection, primarily due to establishment of the role of herpesvirus in the course of diseases previously considered as non-infectious, and definition of their aggravating influence on the course of human chronic diseases, which is accompanied by deviation in immunological homeostasis, because despite differences in etiology, pathogenesis, clinic, morphological nature and consequences, all diseases are combined by a single common immunopathological mechanism.

  STAFF

  Topics of the laboratory

1. The role of the Herpesviridae viruses in the etiology and pathogenesis of diseases of the cardiovascular system:

"Herpesvirus (HSV-1, HSV-2, CMV) in the process of atherogenesis: virological, immunological, clinical parallel" (1999-2001) - was awarded as the best research in AMS system

"The impact of immunological disorders on the course of acute coronary syndrome in patients with persistent herpesviral infection" (2009-2011) - awarded as the best research in NAMS system

"The correlation paradigm between herpesvirus infection and chronic somatic diseases in immunocompetent persons" (2012-2014)

"Improving the noninvasive diagnostics of chronic viral myocarditis" (2015-2017)

 

2. Establishment of basic immunological patterns of vaccination process development, mechanisms and factors which affect it. Immunological aspects of herpesvirus persistence:

"Immunological aspects of viral persistence" (2012-2014)

"Developing new approaches to creating viral vaccines, study of their specific activity dependency on the type and degree of modification components" (2013-2015)

"Features of vaccine-induced immunity formation after routine vaccination of children with chronic herpesvirus infection" (2015-2017)

LABORATORY OF IMMUNOREHABILITOLOGY

  Monograph

  • Mechanisms of prokaryote genome variability / Ed. Volianskii Yu.; Kuchma I., Kolotova T., Shyrobokov V., Volianskii A., Palii G., Stegnii M., Iankovskii D. – Kharkov: NTMT, 2011. – 319 p.

  Diplomas

  • Silver diploma of the XVI International Scientific and Practical Conference "Problems and ways of modern public health development" held in the period from December 21 to 26 2011 in London in the framework of the preliminary programme of the project of International Academy of Sciences and Higher Education "World Championship, continental, national and regional research analytics championships".
  • Biologically active substances of lipophilic fractions of herbs of genera Artemisia L., Potentilla L., Melilotus L. and research of their antimicrobial activity. Ochkur A., Kashpur N., Kovalyova A. – 2011. – P. 437-443.

  Publications

  • Volyanskiy A. Prevalence of some clinically significant infections in Ukraine, the potential risks for nation health / A. Volyanskiy, S. I. Pokhyl // Environmental Forensics. 2011. – P. 194–198.
  • The effect of thyroxine on the activity of thyroid and prooxidant-antioxidant systems of rats under ADT-anatoxin immunization / A. Volyanskiy, I. Kuchma, Yu. Nikitchenko, L. Simirenko // Annales Universitatis Mariae Curie-Sklodowska, Lublin-Polonia. – 2008. – Vol. XXI, N 2 (64). – P. 325- 328.
  • Volianskyi A. Cytokine reaction of the body during post-vaccination period / A. Volianskyi // Infectious diseases. – 2012. – Vol. I (67). – P. 39-45.
  • Мartynov А.V., Smelyanskaya M.V. Antiproliferative properties of chemically modified a-2b-recombinant interferon // J. of Interf. & Cytokine res. – 2005. – Vol. 25, №7. – P. 414-417
  • Kuchma I.Yu., Volyansky A.Yu., Moskalenko V.F., Tkachuk T.B., Dobroskok A.I., Martynov A.V., Smelyanskaya M.V., Peremot S.D. Using of cis-aconitic acid phenylimides in liposomal form for herpes treatment // J. Micr.Epid.Immunobiol. – 2000. – №5. – P. 58-61
  • Martynov A.V., Shmatko Yu.V., Smelyanskaya M.V., Peremot S.D., Vinnik Yu.M. Detection of herpes virus type 1 antigen in lymphocytes and tumor tissue of patients with cancer of uterus // Exp. Oncology. – 2002. – Vol. 24, №2. – P. 120-122
  • Prohoriatova E., Panchenko L., Volianskii Yu., Smelianskaia M. Optimizing conditions for the use of cellular cultures for virus indication by the method of fluorescent probes // Clinical Laboratory Diagnostics. – 1995. – №5. – P. 52-54
  • Hodak L., Navet T., Makarenko V., Smelianskaia M. Cytomegalovirus infection as an indicator of ecological trouble with cramps in children // Pediatrics, Obstetrics and Gynecology. – 1996. – №3 – P. 19-21
  • Prokhoriatova E., Volianskii Yu., Babkin V., Panchenko L., Smelianskaia M. Fluorescent probes method application for the diagnosis of coronavirus acute intestinal infections in humans // Microbiological Journal. – 1997. – Vol.59, №3. – P. 86-90
  • Smilianska M. Laboratory diagnostics of cytomegalovirus infection // Infectious Diseases. – №2. – 1998. – P. 50-52
  • Smelianskaia M. Cytomegalovirus as etiological factor in various eye diseases // Journal of Ophthalmology. – №4. – 1998. – P. 310-311
  • Peremot S., Tseluiko V., Rudyk Y., Smelianskaia M. Herpesvifidae impact on the course of coronary heart disease // Ukrainian Journal of Cardiology. – 2000. – №3. – P. 30-33
  • Rudyk Y., Peremot S., Smelianskaia M. Links between Chlamydia infection and coronary heart disease // Ukrainian Journal of Cardiology. – 2000. – №4. – P. 42-46
  • Rudyk Yu., Zhmuro A, Peremot S.,Smelyanskaya M. Links between viral and bacterial infection and ischemic heart disease: Ukrainian pattern // 3 International Congress on Coronary Artery Disease. – Lyon, France, – 2000. – P. 144.
  • Sirenko I., Shmatko S., Peremot S., Smelianskaia M. Marchenko O., Podoprigora N. Impact of cytomegalovirus infection on the course of tuberculosis in children and adolescents // Problems of Tuberculosis and Lung Disease. – 2003. – № 8. – P. 7-9
  • Martynov A., Peremot S., Smilianska M., Sorochan P., Nikiforova N. Relationship between herpesvirus persistence in immune cells and the immune system condition in cancer patients // Journal of the Academy of Medical Sciences of Ukraine. – 2004. – Vol.10, № 2. – P. 385-391
  • Peremot S.D., Smelyanskaya M.V., Martinov A.V., Peremot J.A. The role of herpesviruses in the development of coronary heart disease complications // Annals of Mechnicov Institute, №4. – 2008. – Р. 22-25
  • Smelyanskaya M., Kashpur N., Peremot S. Etiologic factor in the development of myocarditis in Kharkov region // Annals of Mechnicov Institute. – 2016. – №3. – P. 45-48.
  • Tseluiko V., Rudenko A., Peremot Y., Yakovleva L. Peremot S., Kinoshenko K. The results of long-term observation of patients with coronary heart disease after surgery // Heart and Blood Vessels. – 2011. – №1 (33). – P. 65-70.
  • Volianskyi A. Relationship between specific vaccine-induced and systemic immunity in immunocompromised children [Electronic resource] / A. Volianskyi // Annals of Mechnicov Institute. – 2012. – № 1. – P. 23-29. Access to the journal: www.imiamn.org.ua/journal.htm.
  • Vaccination tactics of children who often get sick and means to enhance its effectiveness [Newsletter] / Volianskyi A, Romanova O., Konoreva K., Davidova T. – Annals of Mechnicov Institute. – 2012. – № 1. – P. 56-57. Access to the journal: www.imiamn.org.ua/journal.htm
  • Optimization of routine vaccination of children who often get sick [Newsletter] / Volyansky A, Romanova O., Konoreva K., Davydova T. – Annals of Mechnicov Institute. – 2012. – № 4. – P. 189-190. Access to the journal: www.imiamn.org.ua/journal.htm
  • Kashpur N. Research on the effect of Galium verum lipophilic fractions on the adhesive properties of microorganisms / N. Kashpur, O. Hariacha, A. Volianskyi, T. Iliina // Ukrainian Journal of Clinical and Laboratory Medicine. – 2011. – № 1. – Р. 78-81.
  • Kashpur N. Research on the effect of Galium verum lipophilic fractions on the anti-lysozyme properties of microorganisms / N. Kashpur, O. Hariacha, A. Volianski, T. Iliina // Сlinical Pharmacy. – 2011. – Vol. 15, № 1. – P. 43-45.
  • Kashpur N. Antifungal activity of lipophilic fractions of plants of the family Galium. Paper 1 / N. Kashpur, O. Hariacha, A. Volianskyi, T. Iliina // Сlinical Pharmacy. – 2011. – Vol. 15, № 4. – P. 50-53
  • Kashpur N. Antifungal activity of lipophilic fractions of plants of the family Galium. Paper 2 / N. Kashpur, O. Hariacha, A. Volianskyi, T. Iliina // Сlinical Pharmacy. – 2012. – Vol. 16, № 1. – P. 48 – 51
  • Honcharov N. Research on the allergenic effect of lipophilic plant extracts / N. Honcharov, N. Kashpur, A. Kovalova, T. Iliina // Allergology and Immunology.- XVII International Congress of Rehabilitation Medicine and immunorehabilitation. V World Forum on asthma and respiratory allergies. – New York, USA. April 21-24, 2012. – Volume 13, № 1. – P. 119-120. ISSN 1562-3637
  • Iurchenko, N. The Research of Antimicrobial Activity of Asperula Humifusa M. Bieb Besser Phenolic Complex [Text] / N. Iurchenko, N. Kashpur, A. Kovalyova, T. Ilyina // The pharma innovation – journal. – 2013. – Vol. 2, № 4. – P. 89-91. ISSN: 2277- 7695

LABORATORY OF IMMUNOREHABILITOLOGY

  Patents

  • Publication number: UA 55618, IPC A61B5/021; G01N33/53 / Method for prognosing of risk of acute coronary syndrome in patients with coronary heart disease, infected with viruses of the family Herpesviridae / Volianskyi A., Kuchma I., Peremot S., Kashpur N., Sydorenko T., Smilianska M. /аpplication number: u201003571 from 29.03.2010; рublication date: 27.12.2010; newsletter № 24, 2010.
  • Publication number: UA 99042, IPC A61K 36/74 (2006.01), A61K 135/00 (2006.01), A61P 31/04 (2006.01) / Process for the preparation of lipophilic complex of antimicrobic action / Goncharov N., Kovaliova A., Iliina T., Kashpur N. /аpplication number: а2011_02084 from 22.02.2011; рublication date: 10.07.2012; newsletter № 13, 2012.
  • Publication number: UA 104173, IPC A61K 36/282 (2006.01), A61P 31/00 / Method for producing product with antimicrobial activity from plant raw materials / Ochkur O., Kashpur N., Honcharov N., Kovaliova A., Iliina T. /аpplication number: u2011 12754 from 31.10.2011; рublication date: 10.01.2014; newsletter № 1, 2014.
  • Publication number: UA 97513, IPC C12N 1/00 (2015.01) / Method for determining viral load / applicants: Volianskyi A., Smilianska M., Peremot S., Kashpur N., Ovcharenko S. / аpplication number: u201405696 from 26.05.2014; рublication date: 25.03.2015; newsletter № 6, 2014.
  • Publication number: UA 105324, IPC G01N 21/00 (2016.01) / Method for lymphocyte functional activity assessment using the Agilent 2100 Bioanalyzer / Volianskyi A., Smilianska M., Peremot S., Kashpur N. /аpplication number: u201509727 from 07.10.2015; рublication date: 10.03.2016; newsletter № 5, 2016.
  • Publication number: UA 112852, IPC C12N 5/02 (2006.01) / Method for increasing multiplicity of viral antigens / DNA in blood lymphocytes / Volianskyi A., Smilianska M., Peremot S., Kashpur N. /аpplication number: u201608216 from 25.07.2016; рublication date: 26.12.2016; newsletter № 24, 2016.
  • Publication number: UA 71014, IPC (2012.01) А61В 10/00; G01N 33/50 (2006.01) / Method for express estimation of vaccination efficiency / Volianskyi A., Romanova O., Kuchma I., Krestetska S. /аpplication № u201201011 from 31.01.2012; рublication date: 25.06.2012; newsletter № 12, 2012.