Currently, the laboratory is accumulating fundamentally new information on the role of infectious agents, particularly herpesvirus, in general human pathology, the logical conclusion of which is expected to result in the development of a new concept of the role and importance of persistent intracellular infections both in general human pathology and in adaptive capacity of the body under physiological conditions of existence.
The considerable expansion of infectious diseases requires the formation of a new paradigm of herpesvirus infection, primarily due to establishment of the role of herpesvirus in the course of diseases previously considered as non-infectious, and definition of their aggravating influence on the course of human chronic diseases, which is accompanied by deviation in immunological homeostasis, because despite differences in etiology, pathogenesis, clinic, morphological nature and consequences, all diseases are combined by a single common immunopathological mechanism.
1. The role of the Herpesviridae viruses in the etiology and pathogenesis of diseases of the cardiovascular system:
"Herpesvirus (HSV-1, HSV-2, CMV) in the process of atherogenesis: virological, immunological, clinical parallel" (1999-2001) - was awarded as the best research in AMS system
"The impact of immunological disorders on the course of acute coronary syndrome in patients with persistent herpesviral infection" (2009-2011) - awarded as the best research in NAMS system
"The correlation paradigm between herpesvirus infection and chronic somatic diseases in immunocompetent persons" (2012-2014)
"Improving the noninvasive diagnostics of chronic viral myocarditis" (2015-2017)
2. Establishment of basic immunological patterns of vaccination process development, mechanisms and factors which affect it. Immunological aspects of herpesvirus persistence:
"Immunological aspects of viral persistence" (2012-2014)
"Developing new approaches to creating viral vaccines, study of their specific activity dependency on the type and degree of modification components" (2013-2015)
"Features of vaccine-induced immunity formation after routine vaccination of children with chronic herpesvirus infection" (2015-2017)